Major Metabolites of Ginseng Sapogenins formed by Rat Liver Microsomes.
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منابع مشابه
Oxidative metabolism of BDE-99 by rat liver microsomes: metabolites formed and CYP enzymes involved
Introduction 2,2ʹ,4,4ʹ,5-Pentabromodiphenyl ether (BDE-99) is the major congener in the widely-used commercial penta-brominated diphenyl ether (BDE) mixture and has become a widely distributed environmental contaminant (Hites 2004). Hydroxy-BDEs have been identified in humans and other vertebrate species (Athanasiadou et al. 2008, Marsh et al. 2004, McKinney et al. 2006, Qiu et al. 2009) but th...
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20(S)-Ginsenoside Rg₂ (1) has recently become a hot research topic due to its potent bioactivities and abundance in natural sources such as the roots, rhizomes and stems-leaves of Panax ginseng. However, due to the lack of studies on systematic metabolic profiles, the prospects for new drug development of 1 are still difficult to predict, which has become a huge obstacle for its safe clinical u...
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published by admin on Fri, 03/14/2014 8:53am Title Digitoxin metabolism by rat liver microsomes. Publication Type Journal Article Year of Publication 1975 Authors Schmoldt, A, Benthe, HF, Haberland, G Journal Biochem Pharmacol Volume 24 Issue 17 Pagination 1639-41 Date Published 1975 Sep 1 ISSN 0006-2952
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The metabolism of 1-nitropyrene by rat liver 9000 X g supernatant was investigated. Under aerobic conditions, ring oxidation to 1-nitropyren-3-ol, 1-nitropyren-6-ol, 1-nitropyren-8-ol, and 4,5-dihydro-4,5-dihydroxy-1-nitropyrene and nitroreduction to 1-aminopyrene were observed. Metabolites were identified by their ultraviolet, mass, and nuclear magnetic resonance spectra; by chemical transform...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2000
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.48.1226